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Progress in Medical Sciences ISSN: 2577 - 2996
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Progress in Medical Sciences. 2025; 9(4):(226-229)
doi: doi.org/10.47363/PMS/2025(9)241


3D Genomics: Visualizing DNA in 3D for Precision Medicine

Arjun Deshraje Urs

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Abstract
Conventional genomic analyses, constrained by linear representations, inadequately capture the spatial organization of chromatin, which is fundamental to gene regulation, epigenetic modulation, and pathological transformation. Three-dimensional (3D) genomics, a core domain within spatial genomics, facilitates the reconstruction and interrogation of chromatin topologies in their native nuclear milieu. This paper explores the technological, algorithmic, and translational dimensions of 3D genomics, emphasizing its potential to elucidate regulatory architectures and drive personalized therapeutic paradigms in precision medicine. We present a synthesis of high-resolution methodologies, integrative computational frameworks, and disease centric case applications, positioning spatial genomics as a cornerstone of next-generation biomedical strategies.